Wolves did not mate with modern dogs, they evolved into them, and can still produce fertile offspring to this day.
So how do we know that is not the same thing that happened between humans and neanderthals/denisovans?
via Why do scientists think that Neanderthals and Modern Humans mated with each other rather than just sharing the same DNA through evolution? : AskAnthropology.
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Born in 1964, business owner, from Woodbridge, VA, owns ExcitingAds! Inc. (http://www.excitingads.com) and blog (https://search.excitingads.com). He was born in Mirpurkhas, Sind, Pakistan. His elementary school was ST. Michael's Convent High School, Mirpurkhas, Sind, Pakistan. Graduated high school from ST. Bonaventure's Convent High School, Hyderabad, Sind, Pakistan. His pre-med college was S. A. L. Govt. College, Mirpurkas, Sind, Pakistan. Graduated from Liaquat University of Medical and Health Sciences, Jamshoro, Sind, Pakistan in 1990. Earned equivalency certification from Educational Commission for Foreign Medical Graduates, Philadelphia, PA in 1994.
