Invertebrate receptor nucleic acids isolated from Drosophila melanogaster are described. Invertebrate nucleic acid and protein can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in expression or mis-expression of the invertebrate receptor protein. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds that are potential pesticidal agents or therapeutics that interact with the invertebrate receptor protein. They can also be used in methods for studying invertebrate receptor activity and identifying other genes that modulate the function of, or interact with, the invertebrate receptor gene.
Source: Patent WO2001038359A2 – Drosophila nicotinic acetylcholine receptor – Google Patents
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