In some aspects, the present disclosure provides for a pulsatile or extended release dosage form for once or twice-daily administration, said form comprising a capsule or tablet comprising an effective amount of nicotine for treatment of symptoms of Parkinson’s Disease or symptoms associated with dopaminergic treatment of Parkinson’s Disease, wherein said capsule or tablet exhibits extended or pulsatile release of said nicotine. In various aspects, said pulsatile release comprises a first and second release peak, wherein said first release peak occurs within about two hours of administration to a patient, and said second release peak occurs between about two and about twelve hours of administration to a patient.
Source: Patent WO2013006643A1 – Compositions and methods for treatment of symptoms in parkinson’s disease … – Google Patents
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